ACTA VETERINARIA ET ZOOTECHNICA SINICA ›› 2018, Vol. 49 ›› Issue (10): 2080-2085.doi: 10.11843/j.issn.0366-6964.2018.10.003

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Research Progress of Trophectoderm Development of Early Embryo in Mammals

ZHANG Yan-yan, PENG Hui, XIAO Tian-fang*   

  1. College of Animal Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China
  • Received:2018-01-17 Online:2018-10-23 Published:2018-10-23

Abstract:

During the blastocyst development, embryonic blastomeres were differentiated into trophectoderm and inner cell mass. After the blastocyst hatching, trophectoderm was differentiated into polar trophoblast and mural trophoblast.The differentiation of trophectoderm was very important for early embryonic development in mammals. Tead 4, Cdx 2 and Eomes are primary genes affecting trophectoderm development and knockout or mutation of these genes result in incorrect differentiation of trophectoderm. While the integrality, permeability and fluid transport function of trophectoderm were disfigured, which further led to the failure of blastocyst formation. We comprehensively discussed the development process of trophectoderm, pivotal genes for its formation, key proteins related to its integrality and function as well as underlying potential relationship between these key proteins and pivotal genes, which may provide information for further understanding the molecular mechanisms regulating embryonic trophectoderm development in mammals.

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